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EDUCATION AND RESEARCH EXPERIENCE
| 1978-1982 |
B.S., Xiamen University, China |
| 1982-1988 |
Ph.D., University of California, Los Angeles, USA |
| 1988-1990 |
Postdoctoral Fellow, Stanford University, USA |
| 1990-1993 |
Research Fellow, Institute of Molecular & Cellular Biology, Singapore |
| 1993-1995 |
Associate Professor, Xiamen University, China |
| 1995-1998 |
Senior Research Fellow, Stanford University, USA |
| 1998-2004 |
Chief Scientific Officer, BioSun Technologies, USA/China |
| 2004-Now |
Professor, University of Science and Technology of China |
RESEARCH INTERESTS
| 1) |
Autophagy modulation by engineered nanomaterials; |
| 2) |
Targeted and controlled drug delivery using nano-structured carriers; |
| 3) |
Transdermal drug development and formulations; |
| 4) |
Other special areas of nanobiology. |
CURRENT RESEARCH PROJECTS
| 1) |
Nanomaterial-induced autophagy: molecular mechanism, biosafty and applicaltions in cancer diagnosis and therapy. National Basic Research Program of China (2013CB933902; 2012-2017). |
| 2) |
Modulating the blood retention time and biodistribution for theranostic nanoparticles through circulation-prolonging and surface-coating peptides obtained through phage display. National Natural Science Foundation of China, Key Project (2015-2019) |
REPRESENTATIVE PUBLICATIONS
| 1) |
Chen YP, Shen YY, Guo X, Zhang CS, Yang WJ, Ma ML, Liu S, Zhang MB, Wen LP*. Transdermal protein delivery by a co-administered peptide identified via phage display. Nature Biotechnology 24：455-50 (2006). |
| 2) |
Zhang YJ, Zheng F, Yang TL, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou QQ, Zhang Y, Li ZQ & Wen LP*.Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nature Materials. 11, 817–826 (2012) |
| 3) |
Zhang Q, Yang WJ, Man N, Zheng F, Shen YY, Sun KJ, Li Y and Wen LP*. Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal. Autophagy 5(8)：1107-17 (2009). |
| 4) |
Yu L, Lu Y, Man N, Yu SH, Wen LP*. Rare earth oxide nanocrystals induce autophagy in HeLa cells. Small. 5(24):2784-87 (2009). |
| 5) |
Man N,Yu L, Yu SH and Wen LP* .Rare earth oxide nanocrystals as a new class of autophagy inducers. Autophagy 6，2：310-11(2010). |
| 6) |
Man N, Chen Y, Zheng F, Zhou W and Wen LP*. Induction of Genuine Autophagy by Cationic Lipids In Mammalian Cells. Autophagy 6，4：449-54 (2010). |
| 7) |
Lu Y, Zhang L, Li J, Su YD, Liu Y, Xu YJ, Dong L, Gao HL, Lin J, Man N, Wei PF, Xu WP, Yu SH* and Wen LP*. MnO nanocrystals: A platform for integration of MRI and genuine autophagy induction for chemotherapy. Adv. Funct. Mater., 23: 1534–1546. (2012). |
| 8) |
Dong L, Liu Y, Lu Y, Zhang L, Man N, Cao L, Ma K, An D, Lin J, Xu YJ, Xu WP, Wu WB, Yu SH* and Wen LP*. Tuning Magnetic Property and Autophagic Response for Self-Assembled Ni-Co Alloy Nanocrystals. Adv. Funct. Mater. 23: 5930–5940. (2013) |
| 9) |
Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang Y, Zheng F, Zhang J, Xu J, Hu Y, Wang Y, Li Y, Gu N, Wen LP*.Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy. 2;10(11):2006-20. (2014) |
| 10) |
Miao YY, Xu J, Shen Y, Chen L, Bian YP, Hu Y, Zhou W, Zheng F, Man N, Shen YY, Zhang YJ, Wang M*, and Wen LP*. Nanoparticle as Signaling Protein Mimic: Robust Structural and Functional Modulation of CaMKII upon Specific Binding to Fullerene C60 Nanocrystals. ACS Nano. 8 (6), pp 6131–6144. (2014) |
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